The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.

The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.

Chromosomal translocations are primary events in the development of leukemias, representing at least one genetic feature of the putative cancer stem cell. Studies of genes influenced by chromosomal translocations have yielded a vast amount of information about how cancer is initiated and maintained....

Полное описание

Библиографические подробности
Главные авторы:	Nam, C, Rabbitts, T
Формат:	Journal article
Язык:	English
Опубликовано:	2006

Схожие документы

The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
по: McCormack, M, и др.
Опубликовано: (2003)

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.
по: Utpal P Davé, и др.
Опубликовано: (2009-05-01)

Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.
по: McCormack, M, и др.
Опубликовано: (2004)

The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
по: McCormack, M, и др.
Опубликовано: (2010)

High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic leukemia
по: Lili Wu, и др.
Опубликовано: (2015-06-01)

Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
по: Tse, E, и др.
Опубликовано: (2004)

T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
по: Drynan, L, и др.
Опубликовано: (2001)

An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions.
по: Nam, C, и др.
Опубликовано: (2008)

Chromosomal translocation master genes, mouse models and experimental therapeutics.
по: Rabbitts, T
Опубликовано: (2001)

Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
по: Lobato, M, и др.
Опубликовано: (2008)

Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model
по: Pais, H, и др.
Опубликовано: (2019)

Identification of a high incidence region for retroviral vector integration near exon 1 of the <it>LMO2 </it>locus
по: Sakashita Kazuo, и др.
Опубликовано: (2009-09-01)

Chromosomal translocation products engender new intracellular therapeutic technologies.
по: Rabbitts, T, и др.
Опубликовано: (2003)

Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.
по: Appert, A, и др.
Опубликовано: (2009)

The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice.
по: Yamada, Y, и др.
Опубликовано: (2000)

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.
по: Hasemann, MS, и др.
Опубликовано: (2008)

The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism.
по: Collins, E, и др.
Опубликовано: (2002)

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
по: Stephen Smith, и др.
Опубликовано: (2014-01-01)

The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis
по: Yoshihiro Yamada, и др.
Опубликовано: (2022-05-01)

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.
по: McCormack, M, и др.
Опубликовано: (2013)

Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
по: Collins, E, и др.
Опубликовано: (2002)

Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.
по: Gering, M, и др.
Опубликовано: (2003)

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
по: Steven Goossens, и др.
Опубликовано: (2019-08-01)

LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
по: Ruggero, K, и др.
Опубликовано: (2016)

LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
по: Ruggero, K, и др.
Опубликовано: (2016)

Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma
по: Divya Bansal, и др.
Опубликовано: (2023-01-01)

Chromosomal translocation engineering to recapitulate primary events of human cancer.
по: Forster, A, и др.
Опубликовано: (2005)

The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target.
по: Yamada, Y, и др.
Опубликовано: (2002)

Application of Chromosome Conformation Capture Method for Detection MYC/TRD Chromosomal Translocation in Leukemia Cell Line
по: Moloud Absalan, и др.
Опубликовано: (2020-07-01)

Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex
по: Sewell, H, и др.
Опубликовано: (2014)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription.
по: Ali, H, и др.
Опубликовано: (2013)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription
по: Ali, H, и др.
Опубликовано: (2013)

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia
по: Rahman, Sunniyat, и др.
Опубликовано: (2018)

Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements
по: Irene Homminga, и др.
Опубликовано: (2012-02-01)

Ku70 affects the frequency of chromosome translocation in human lymphocytes after radiation and T-cell acute lymphoblastic leukemia
по: Zhenbo Cheng, и др.
Опубликовано: (2022-08-01)

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.
по: El Omari, K, и др.
Опубликовано: (2011)

Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias.
по: Cano, F, и др.
Опубликовано: (2008)

Deletion, insertion and translocation of DNA sequences contribute to chromosome size polimorphism in Plasmodium berghei
по: Chris J. Janse, и др.
Опубликовано: (1992-01-01)

Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens.
по: Jeroen de Ridder, и др.
Опубликовано: (2006-12-01)

Adult T-cell leukemia/lymphoma: A retroviral malady
по: Anza Khader, и др.
Опубликовано: (2012-01-01)