Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study.
BACKGROUND: Alzheimer's disease and other types of dementia are characterised by numerous psychiatric and behavioural changes. Little is known of their natural history. AIMS: To investigate the sequence and pattern of these changes throughout the course of dementia. METHOD: One hundred people,...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797078077640015872 |
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| author | Hope, T Keene, J Fairburn, C Jacoby, R McShane, R |
| author_facet | Hope, T Keene, J Fairburn, C Jacoby, R McShane, R |
| author_sort | Hope, T |
| collection | OXFORD |
| description | BACKGROUND: Alzheimer's disease and other types of dementia are characterised by numerous psychiatric and behavioural changes. Little is known of their natural history. AIMS: To investigate the sequence and pattern of these changes throughout the course of dementia. METHOD: One hundred people, initially living at home with carers, entered a prospective, longitudinal study. At four-monthly intervals, behavioural and psychiatric symptoms were assessed using the Present Behavioural Examination and Mini-Mental State Examination. Follow-up continued for up to nine years (mean 3.3 years; s.d. 2.4). Patterns of onset and disappearance of these symptoms, their sequence and association with time of death and cognitive decline were analysed. Autopsy confirmed a diagnosis of pure Alzheimer's disease in 48 subjects. Data for this subgroup are presented. RESULTS: Some changes tend to occur earlier than others but changes can occur at almost any time in the course of dementia. CONCLUSIONS: The natural history of behaviour changes in Alzheimer's disease shows great individual variation although some changes tend to follow a recognisable sequence. |
| first_indexed | 2024-03-07T00:27:18Z |
| format | Journal article |
| id | oxford-uuid:7e93a21b-6f0d-4676-88b5-cde961fc5f2e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:27:18Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:7e93a21b-6f0d-4676-88b5-cde961fc5f2e2022-03-26T21:10:55ZNatural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e93a21b-6f0d-4676-88b5-cde961fc5f2eEnglishSymplectic Elements at Oxford1999Hope, TKeene, JFairburn, CJacoby, RMcShane, RBACKGROUND: Alzheimer's disease and other types of dementia are characterised by numerous psychiatric and behavioural changes. Little is known of their natural history. AIMS: To investigate the sequence and pattern of these changes throughout the course of dementia. METHOD: One hundred people, initially living at home with carers, entered a prospective, longitudinal study. At four-monthly intervals, behavioural and psychiatric symptoms were assessed using the Present Behavioural Examination and Mini-Mental State Examination. Follow-up continued for up to nine years (mean 3.3 years; s.d. 2.4). Patterns of onset and disappearance of these symptoms, their sequence and association with time of death and cognitive decline were analysed. Autopsy confirmed a diagnosis of pure Alzheimer's disease in 48 subjects. Data for this subgroup are presented. RESULTS: Some changes tend to occur earlier than others but changes can occur at almost any time in the course of dementia. CONCLUSIONS: The natural history of behaviour changes in Alzheimer's disease shows great individual variation although some changes tend to follow a recognisable sequence. |
| spellingShingle | Hope, T Keene, J Fairburn, C Jacoby, R McShane, R Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study. |
| title | Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study. |
| title_full | Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study. |
| title_fullStr | Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study. |
| title_full_unstemmed | Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study. |
| title_short | Natural history of behavioural changes and psychiatric symptoms in Alzheimer's disease. A longitudinal study. |
| title_sort | natural history of behavioural changes and psychiatric symptoms in alzheimer s disease a longitudinal study |
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