Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Stem and progenitor cells have the capacity to balance self-renewal and differentiation. Hematopoietic myeloid progenitors replenish more than 25 billion terminally differentiated neutrophils every day under homeostatic conditions and can increase this output in response to stress or infection. At w...

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Bibliographic Details
Main Authors: Blanco, MA, Sykes, DB, Gu, L, Wu, M, Petroni, R, Karnik, R, Wawer, M, Rico, J, Li, H, Jacobus, WD, Jambhekar, A, Cheloufi, S, Meissner, A, Hochedlinger, K, Scadden, DT, Shi, Y
Format: Journal article
Language:English
Published: Cell Press 2021