Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP-glucose: glycoprotein glucosyl-transferase

Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP-glucose: glycoprotein glucosyl-transferase

UDP-glucose:glycoprotein glucosyltransferase (UGGT) flags misfolded glycoproteins for ER retention. We report crystal structures of full-length Chaetomium thermophilum UGGT (CtUGGT), two CtUGGT double-cysteine mutants, and its TRXL2 domain truncation (CtUGGT-ΔTRXL2). CtUGGT molecular dynamics (MD) s...

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Autors principals:	Modenutti, CP, Capurro, JIB, Ibba, R, Alonzi, DS, Song, MN, Vasiljević, S, Kumar, A, Chandran, AV, Tax, G, Marti, L, Hill, JC, Lia, A, Hensen, M, Waksman, T, Rushton, J, Rubichi, S, Santino, A, Martí, MA, Zitzmann, N, Roversi, P
Format:	Journal article
Idioma:	English
Publicat:	Cell Press 2020

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