GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells.
Prolactin release from columns of dispersed rat anterior pituitary cells was inhibited by GABA and the GABA agonist muscimol. The log dose-response curves for GABA and muscimol appeared to be parallel, but were not parallel to that for dopamine. Two GABA antagonists, bicuculline and picrotoxin, bloc...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1981
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| _version_ | 1797078115707518976 |
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| author | Grossman, A Delitala, G Yeo, T Besser, G |
| author_facet | Grossman, A Delitala, G Yeo, T Besser, G |
| author_sort | Grossman, A |
| collection | OXFORD |
| description | Prolactin release from columns of dispersed rat anterior pituitary cells was inhibited by GABA and the GABA agonist muscimol. The log dose-response curves for GABA and muscimol appeared to be parallel, but were not parallel to that for dopamine. Two GABA antagonists, bicuculline and picrotoxin, blocked the action of both GABA and muscimol, but the dopamine antagonists metoclopramide and perphenazine did not. The data suggest that there are specific GABA receptors on pituitary lactotrophs. |
| first_indexed | 2024-03-07T00:27:52Z |
| format | Journal article |
| id | oxford-uuid:7ec07862-cff1-495a-a63a-2005af962ae2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:27:52Z |
| publishDate | 1981 |
| record_format | dspace |
| spelling | oxford-uuid:7ec07862-cff1-495a-a63a-2005af962ae22022-03-26T21:12:06ZGABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7ec07862-cff1-495a-a63a-2005af962ae2EnglishSymplectic Elements at Oxford1981Grossman, ADelitala, GYeo, TBesser, GProlactin release from columns of dispersed rat anterior pituitary cells was inhibited by GABA and the GABA agonist muscimol. The log dose-response curves for GABA and muscimol appeared to be parallel, but were not parallel to that for dopamine. Two GABA antagonists, bicuculline and picrotoxin, blocked the action of both GABA and muscimol, but the dopamine antagonists metoclopramide and perphenazine did not. The data suggest that there are specific GABA receptors on pituitary lactotrophs. |
| spellingShingle | Grossman, A Delitala, G Yeo, T Besser, G GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells. |
| title | GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells. |
| title_full | GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells. |
| title_fullStr | GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells. |
| title_full_unstemmed | GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells. |
| title_short | GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells. |
| title_sort | gaba and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells |
| work_keys_str_mv | AT grossmana gabaandmuscimolinhibitthereleaseofprolactinfromdispersedratanteriorpituitarycells AT delitalag gabaandmuscimolinhibitthereleaseofprolactinfromdispersedratanteriorpituitarycells AT yeot gabaandmuscimolinhibitthereleaseofprolactinfromdispersedratanteriorpituitarycells AT besserg gabaandmuscimolinhibitthereleaseofprolactinfromdispersedratanteriorpituitarycells |