Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.

Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.

beta-Lactam inhibitors of transpeptidase enzymes involved in cell wall biosynthesis remain among the most important therapeutic agents in clinical use. beta-Lactams have more recently been developed as inhibitors of serine proteases including elastase. All therapeutically useful beta-lactam inhibito...

書目詳細資料
Main Authors:	Wilmouth, R, Westwood, N, Anderson, K, Brownlee, W, Claridge, T, Clifton, I, Pritchard, G, Aplin, RT, Schofield, C
格式:	Journal article
語言:	English
出版:	1998

相似書籍

Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors
由: Westwood, N, et al.
出版: (1997)

Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.
由: Wilmouth, R, et al.
出版: (1997)

Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes
由: Wilmouth, R, et al.
出版: (2000)

Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
由: Wilmouth, R, et al.
出版: (1999)

'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes.
由: Wright, P, et al.
出版: (2000)

Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein.
由: Wright, P, et al.
出版: (2001)

Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta-lactamase catalysis.
由: Aplin, RT, et al.
出版: (1990)

Synthesis of delta-lactam (2-oxopiperazine) inhibitors of elastase
由: Seibel, J, et al.
出版: (2005)

Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.
由: Seibel, J, et al.
出版: (2003)

STUDIES ON THE INHIBITION OF PORCINE PANCREATIC ELASTASE USING ELECTROSPRAY MASS-SPECTROMETRY
由: Aplin, R, et al.
出版: (1992)

AN INVESTIGATION INTO THE MECHANISM OF ELASTASE INHIBITION BY CEPHALOSPORINS USING ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY
由: Aplin, R, et al.
出版: (1993)

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.
由: Iqbal, A, et al.
出版: (2009)

The enzymes of beta-lactam biosynthesis
由: Hamed, R, et al.
出版: (2013)

STEREOSELECTIVE PREPARATION OF BETA-AMINO-ACYL IRON COMPLEXES FOR BETA-LACTAM SYNTHESIS
由: Broadley, K, et al.
出版: (1984)

Changes in Circulating Acylated Ghrelin and Neutrophil Elastase in Diabetic Retinopathy
由: Maria Consiglia Trotta, et al.
出版: (2024-01-01)

Enzymatic synthesis of monocyclic beta-lactams.
由: Sleeman, M, et al.
出版: (2002)

beta-lactam synthetase: Implications for beta-lactamase evolution
由: McNaughton, H, et al.
出版: (1998)

The origin of the beta-lactam carbons of clavulanic acid
由: Thirkettle, J, et al.
出版: (1997)

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution.
由: Katona, G, et al.
出版: (2002)

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
由: Aplin, RT, et al.
出版: (1993)

Asymmetric synthesis of beta-lactams and pseudopeptides via stereoselective conjugate additions of lithium (alpha-methylbenzyl)-allylamide to alpha,beta-unsaturated iron acyl complexes
由: Davies, S, et al.
出版: (1999)

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
由: Migaud, M, et al.
出版: (2002)

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
由: Migaud, M, et al.
出版: (2002)

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
由: Brown, R, et al.
出版: (1996)

The enzymes of β-lactam biosynthesis.
由: Hamed, R, et al.
出版: (2013)

Direct N-acylation of lactams, oxazolidinones, and imidazolidinones with aldehydes by Shvo’s catalyst
由: Zhang, Jian, et al.
出版: (2013)

The Survey of Genes Encoding Beta-Lactamases, in Escherichia Coli Resistant to Beta-Lactam and Non-Beta-Lactam Antibiotics
由: Fereshteh Shahcheraghi, et al.
出版: (2010-01-01)

THE ASYMMETRIC-SYNTHESIS OF BETA-LACTAMS
由: Blackburn, B, et al.
出版: (1987)

Beta-lactam-associated hypokalemia
由: Muriel-N. Jansen, et al.
出版: (2024-08-01)

Delabelling beta-lactam allergy
由: Gustavo-Jorge Molina-Molina, et al.
出版: (2024-06-01)

Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation
由: Gayatri, et al.
出版: (2024)

Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives.
由: Brown, R, et al.
出版: (1997)

The OPAT opportunity for beta-lactam individualization
由: Lindsey M. Childs-Kean, et al.
出版: (2024-01-01)

Profile of Enterobacteria Resistant to Beta-Lactams
由: Andressa Liberal Santos, et al.
出版: (2020-07-01)

Staphylococcus saprophyticus: Which beta-lactam?
由: HÃ©lÃ¨ne PailhoriÃ¨s, et al.
出版: (2017-12-01)

Endopeptidase-mediated beta lactam tolerance.
由: Tobias Dörr, et al.
出版: (2015-04-01)

Advances in synthesis of monocyclic beta-lactams
由: Girija S. Singh, et al.
出版: (2014-05-01)

Beta-lactam antibiotics administration among adult inpatients with a beta-lactam allergy label: incidence, predictors, and outcomes
由: Naama Epstein-Rigbi, et al.
出版: (2024-01-01)

Inhibition of human leukocyte and porcine pancreatic elastase by homologues of bovine pancreatic trypsin inhibitor.
由: Kraunsoe, J, et al.
出版: (1996)

Approach for delabeling beta-lactam allergy in children
由: R. Sáenz de Santa María, et al.
出版: (2023-11-01)