Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.
The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected...
| Հիմնական հեղինակներ: | , , , , , , , , , , , , , , , , , , , |
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
Cell Press
2016
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| _version_ | 1826281393377771520 |
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| author | Montes de Oca, M Kumar, R Rivera, F Amante, F Sheel, M Faleiro, R Bunn, P Best, S Beattie, L Ng, S Edwards, C Boyle, G Price, R Anstey, N Loughland, J Burel, J Doolan, D Haque, A McCarthy, J Engwerda, C |
| author_facet | Montes de Oca, M Kumar, R Rivera, F Amante, F Sheel, M Faleiro, R Bunn, P Best, S Beattie, L Ng, S Edwards, C Boyle, G Price, R Anstey, N Loughland, J Burel, J Doolan, D Haque, A McCarthy, J Engwerda, C |
| author_sort | Montes de Oca, M |
| collection | OXFORD |
| description | The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4(+) T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells. Type I IFN-dependent, parasite-specific IL-10 production was also observed in P. falciparum malaria patients in the field following chemoprophylaxis. Parasite-induced IL-10 suppressed inflammatory cytokine production, and IL-10 levels after drug treatment were positively associated with parasite burdens before anti-parasitic drug administration. These findings have important implications for understanding the development of host immune responses following blood-stage P. falciparum infection, and they identify type I IFNs and related signaling pathways as potential targets for therapies or vaccine efficacy improvement. |
| first_indexed | 2024-03-07T00:28:08Z |
| format | Journal article |
| id | oxford-uuid:7ed2251e-5939-4c0c-8ac2-8eb6f8bc6213 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:28:08Z |
| publishDate | 2016 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:7ed2251e-5939-4c0c-8ac2-8eb6f8bc62132022-03-26T21:12:47ZType I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7ed2251e-5939-4c0c-8ac2-8eb6f8bc6213EnglishSymplectic Elements at OxfordCell Press2016Montes de Oca, MKumar, RRivera, FAmante, FSheel, MFaleiro, RBunn, PBest, SBeattie, LNg, SEdwards, CBoyle, GPrice, RAnstey, NLoughland, JBurel, JDoolan, DHaque, AMcCarthy, JEngwerda, CThe development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4(+) T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells. Type I IFN-dependent, parasite-specific IL-10 production was also observed in P. falciparum malaria patients in the field following chemoprophylaxis. Parasite-induced IL-10 suppressed inflammatory cytokine production, and IL-10 levels after drug treatment were positively associated with parasite burdens before anti-parasitic drug administration. These findings have important implications for understanding the development of host immune responses following blood-stage P. falciparum infection, and they identify type I IFNs and related signaling pathways as potential targets for therapies or vaccine efficacy improvement. |
| spellingShingle | Montes de Oca, M Kumar, R Rivera, F Amante, F Sheel, M Faleiro, R Bunn, P Best, S Beattie, L Ng, S Edwards, C Boyle, G Price, R Anstey, N Loughland, J Burel, J Doolan, D Haque, A McCarthy, J Engwerda, C Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection. |
| title | Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection. |
| title_full | Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection. |
| title_fullStr | Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection. |
| title_full_unstemmed | Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection. |
| title_short | Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection. |
| title_sort | type i interferons regulate immune responses in humans with blood stage plasmodium falciparum infection |
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