Developing inhibitors of bromodomain-histone interactions

Developing inhibitors of bromodomain-histone interactions

<p>Lysine acetylation is a widespread protein post-translational modification that influences diverse cellular processes. An association between acetylation of histone N-terminal tails and transcriptional activation has been recognised since the 1960s. However, it has only become apparent sinc...

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Manylion Llyfryddiaeth
Prif Awdur:	Hewings, D
Awduron Eraill:	Conway, S
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2014
Pynciau:	Chemical biology Physical Sciences Organic chemistry Organic synthesis Chemistry & allied sciences

Eitemau Tebyg

Development of small molecule inhibitors of the bromodomain-histone interaction
gan: Rooney, TPC
Cyhoeddwyd: (2014)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
gan: Hay, D
Cyhoeddwyd: (2014)

Palladium mediated allylic fluorination
gan: Hollingworth, C
Cyhoeddwyd: (2013)

Aziridinations of tethered allenes
gan: Feast, GC
Cyhoeddwyd: (2011)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
gan: Poingdestre, SJ
Cyhoeddwyd: (2012)

Development of ligands to target bromodomain-histone interactions
gan: Jennings, L
Cyhoeddwyd: (2015)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
gan: Hewings, D, et al.
Cyhoeddwyd: (2011)

Novel di-branched monosaccharides and imino sugars
gan: Barker, K, et al.
Cyhoeddwyd: (2009)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
gan: Carter, JL
Cyhoeddwyd: (2023)

Olefin metathesis for site-selective protein modification
gan: Lin, YA
Cyhoeddwyd: (2013)

Phosphoramidite ligand design for the enantioselective conjugate addition of alkylzirconium reagents to enones
gan: Roth, PMC
Cyhoeddwyd: (2014)

Alkaloids from transannular iodoaminations
gan: Brock, E
Cyhoeddwyd: (2012)

Palladium-catalysed cyclisations of bromoenynamides in the synthesis and applications of amidodienes
gan: Greenaway, R
Cyhoeddwyd: (2013)

Determining the structures of halogenated marine natural products by total synthesis
gan: Dyson, BS
Cyhoeddwyd: (2011)

Cation-controlled diastereo- and enantioselective synthesis of indolines: an autocatalytic process
gan: Sharma, K
Cyhoeddwyd: (2014)

Towards the total synthesis of calyciphylline A-type Daphniphyllum alkaloids
gan: Michaelides, IN
Cyhoeddwyd: (2014)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
gan: Kaka, N, et al.
Cyhoeddwyd: (2008)

Palladium- and copper-catalysed heterocycle synthesis
gan: Ball, C
Cyhoeddwyd: (2014)

Synthesis and elaboration of heterocycles via palladium-catalyzed C-H functionalization
gan: Gerelle, M
Cyhoeddwyd: (2012)

Studies towards the stereoselective synthesis of alkenes
gan: Arif, T
Cyhoeddwyd: (2011)

Chiral cation-directed asymmetric 5-endo-trig cyclizations
gan: Johnston, CP
Cyhoeddwyd: (2013)

Design and synthesis of inositol phosphate-based probes
gan: Slowey, A
Cyhoeddwyd: (2013)

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
gan: Hodgson, D, et al.
Cyhoeddwyd: (2008)

Asymmetric syntheses of β- and γ-amino acids
gan: Zammit, C
Cyhoeddwyd: (2015)

Reactions of allenylpalladium intermediates in organic synthesis
gan: Daniels, DSB
Cyhoeddwyd: (2013)

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
gan: Donohoe, T, et al.
Cyhoeddwyd: (2011)

Transition metal catalysed C-C bond formation via C-H functionalisation
gan: Truscott, FR
Cyhoeddwyd: (2012)

The synthesis and biology of iminosugars and their precursors
gan: Ayers, B, et al.
Cyhoeddwyd: (2014)

Studies towards the total synthesis of manzamine A
gan: Hawkins, A
Cyhoeddwyd: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
gan: Cordonnier, M, et al.
Cyhoeddwyd: (2011)

Enantiorecognition phenomena in asymmetric synthesis
gan: Yin, J, et al.
Cyhoeddwyd: (2011)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
gan: Pattarakiat, Seankongsuk
Cyhoeddwyd: (2022)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
gan: Rydzik, AM
Cyhoeddwyd: (2014)

Asymmetric synthesis of piperidine alkaloids
gan: Thomson, A, et al.
Cyhoeddwyd: (2012)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
gan: Lenden, P
Cyhoeddwyd: (2011)

Synthesis of mono- and bicyclic azacycles via palladium- and ruthenium-catalysed enynamide cycloisomerisation
gan: Walker, P, et al.
Cyhoeddwyd: (2014)

Halogen bonding interlocked host systems for recognition and sensing of anions
gan: Mullaney, B, et al.
Cyhoeddwyd: (2014)

A glycopore for bacterial sensing
gan: Shanley, SJ
Cyhoeddwyd: (2009)

Novel palladium-catalysed routes to aromatic heterocycles
gan: Pilgrim, B, et al.
Cyhoeddwyd: (2013)

An ion-binding approach to asymmetric allylation reactions
gan: Stovold, CP
Cyhoeddwyd: (2013)