Developing inhibitors of bromodomain-histone interactions

Developing inhibitors of bromodomain-histone interactions

<p>Lysine acetylation is a widespread protein post-translational modification that influences diverse cellular processes. An association between acetylation of histone N-terminal tails and transcriptional activation has been recognised since the 1960s. However, it has only become apparent sinc...

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Bibliografiske detaljer
Hovedforfatter:	Hewings, D
Andre forfattere:	Conway, S
Format:	Thesis
Sprog:	English
Udgivet:	2014
Fag:	Chemical biology Physical Sciences Organic chemistry Organic synthesis Chemistry & allied sciences

Lignende værker

Development of small molecule inhibitors of the bromodomain-histone interaction
af: Rooney, TPC
Udgivet: (2014)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
af: Hay, D
Udgivet: (2014)

Palladium mediated allylic fluorination
af: Hollingworth, C
Udgivet: (2013)

Aziridinations of tethered allenes
af: Feast, GC
Udgivet: (2011)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
af: Poingdestre, SJ
Udgivet: (2012)

Development of ligands to target bromodomain-histone interactions
af: Jennings, L
Udgivet: (2015)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
af: Hewings, D, et al.
Udgivet: (2011)

Novel di-branched monosaccharides and imino sugars
af: Barker, K, et al.
Udgivet: (2009)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
af: Carter, JL
Udgivet: (2023)

Olefin metathesis for site-selective protein modification
af: Lin, YA
Udgivet: (2013)

Phosphoramidite ligand design for the enantioselective conjugate addition of alkylzirconium reagents to enones
af: Roth, PMC
Udgivet: (2014)

Alkaloids from transannular iodoaminations
af: Brock, E
Udgivet: (2012)

Palladium-catalysed cyclisations of bromoenynamides in the synthesis and applications of amidodienes
af: Greenaway, R
Udgivet: (2013)

Determining the structures of halogenated marine natural products by total synthesis
af: Dyson, BS
Udgivet: (2011)

Cation-controlled diastereo- and enantioselective synthesis of indolines: an autocatalytic process
af: Sharma, K
Udgivet: (2014)

Towards the total synthesis of calyciphylline A-type Daphniphyllum alkaloids
af: Michaelides, IN
Udgivet: (2014)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
af: Kaka, N, et al.
Udgivet: (2008)

Palladium- and copper-catalysed heterocycle synthesis
af: Ball, C
Udgivet: (2014)

Synthesis and elaboration of heterocycles via palladium-catalyzed C-H functionalization
af: Gerelle, M
Udgivet: (2012)

Studies towards the stereoselective synthesis of alkenes
af: Arif, T
Udgivet: (2011)

Chiral cation-directed asymmetric 5-endo-trig cyclizations
af: Johnston, CP
Udgivet: (2013)

Design and synthesis of inositol phosphate-based probes
af: Slowey, A
Udgivet: (2013)

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
af: Hodgson, D, et al.
Udgivet: (2008)

Asymmetric syntheses of β- and γ-amino acids
af: Zammit, C
Udgivet: (2015)

Reactions of allenylpalladium intermediates in organic synthesis
af: Daniels, DSB
Udgivet: (2013)

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
af: Donohoe, T, et al.
Udgivet: (2011)

Transition metal catalysed C-C bond formation via C-H functionalisation
af: Truscott, FR
Udgivet: (2012)

The synthesis and biology of iminosugars and their precursors
af: Ayers, B, et al.
Udgivet: (2014)

Studies towards the total synthesis of manzamine A
af: Hawkins, A
Udgivet: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
af: Cordonnier, M, et al.
Udgivet: (2011)

Enantiorecognition phenomena in asymmetric synthesis
af: Yin, J, et al.
Udgivet: (2011)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
af: Pattarakiat, Seankongsuk
Udgivet: (2022)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
af: Rydzik, AM
Udgivet: (2014)

Asymmetric synthesis of piperidine alkaloids
af: Thomson, A, et al.
Udgivet: (2012)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
af: Lenden, P
Udgivet: (2011)

Synthesis of mono- and bicyclic azacycles via palladium- and ruthenium-catalysed enynamide cycloisomerisation
af: Walker, P, et al.
Udgivet: (2014)

Halogen bonding interlocked host systems for recognition and sensing of anions
af: Mullaney, B, et al.
Udgivet: (2014)

A glycopore for bacterial sensing
af: Shanley, SJ
Udgivet: (2009)

Novel palladium-catalysed routes to aromatic heterocycles
af: Pilgrim, B, et al.
Udgivet: (2013)

An ion-binding approach to asymmetric allylation reactions
af: Stovold, CP
Udgivet: (2013)