Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.

Bromodomains, protein modules that recognize and bind to acetylated lysine, are emerging as important components of cellular machinery. These acetyl-lysine (KAc) "reader" domains are part of the write-read-erase concept that has been linked with the transfer of epigenetic information. By r...

书目详细资料
Main Authors:	Hewings, D, Rooney, T, Jennings, L, Hay, D, Schofield, C, Brennan, P, Knapp, S, Conway, S
格式:	Journal article
语言:	English
出版:	2012

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