A method of inducing global cerebral ischemia.
The four-vessel occlusion (4-VO) method of global forebrain cerebral ischemia mimics the human clinical condition of cardiac arrest. It results in selective neuronal damage and is a useful experimental system to dissect underlying mechanisms behind ischemic phenomena such as the differential suscept...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797078209166049280 |
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| author | Hadley, G Papadakis, M Buchan, A |
| author_facet | Hadley, G Papadakis, M Buchan, A |
| author_sort | Hadley, G |
| collection | OXFORD |
| description | The four-vessel occlusion (4-VO) method of global forebrain cerebral ischemia mimics the human clinical condition of cardiac arrest. It results in selective neuronal damage and is a useful experimental system to dissect underlying mechanisms behind ischemic phenomena such as the differential susceptibility of CA1 compared to the CA3 region of the hippocampus. It also provides a "proof-of-principle" system for testing out potential agents for neuroprotection. |
| first_indexed | 2024-03-07T00:28:52Z |
| format | Journal article |
| id | oxford-uuid:7f135f58-326d-4ff3-9cf3-2a32f2330d87 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:28:52Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:7f135f58-326d-4ff3-9cf3-2a32f2330d872022-03-26T21:14:25ZA method of inducing global cerebral ischemia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7f135f58-326d-4ff3-9cf3-2a32f2330d87EnglishSymplectic Elements at Oxford2014Hadley, GPapadakis, MBuchan, AThe four-vessel occlusion (4-VO) method of global forebrain cerebral ischemia mimics the human clinical condition of cardiac arrest. It results in selective neuronal damage and is a useful experimental system to dissect underlying mechanisms behind ischemic phenomena such as the differential susceptibility of CA1 compared to the CA3 region of the hippocampus. It also provides a "proof-of-principle" system for testing out potential agents for neuroprotection. |
| spellingShingle | Hadley, G Papadakis, M Buchan, A A method of inducing global cerebral ischemia. |
| title | A method of inducing global cerebral ischemia. |
| title_full | A method of inducing global cerebral ischemia. |
| title_fullStr | A method of inducing global cerebral ischemia. |
| title_full_unstemmed | A method of inducing global cerebral ischemia. |
| title_short | A method of inducing global cerebral ischemia. |
| title_sort | method of inducing global cerebral ischemia |
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