Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors

The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex.

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Westwood, N, Claridge, T, Edwards, P, Schofield, C
التنسيق: Journal article
اللغة:English
منشور في: 1997
الوصف
الملخص:The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex.