Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors

Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors

The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex.

Bibliografiske detaljer
Main Authors:	Westwood, N, Claridge, T, Edwards, P, Schofield, C
Format:	Journal article
Sprog:	English
Udgivet:	1997

Lignende værker

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