Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors

The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex.

Bibliográfalaš dieđut
Váldodahkkit: Westwood, N, Claridge, T, Edwards, P, Schofield, C
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 1997