Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors
The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex.
| Huvudupphovsmän: | , , , |
|---|---|
| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
1997
|