The changing world of clinical trials 2003-2017: A view from the AspECT trial

The changing world of clinical trials 2003-2017: A view from the AspECT trial

The past two decades have seen dramatic changes in clinical trial conduct and methodology. From trial regulation to data analysis, the rapid rise of randomised control trials (RCTs) has introduced many new techniques. Some methods of designing and conducting RCTs have been widely adopted, whereas ot...

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Autors principals: Reilly, G, Love, S, Wise, A, Scudder, C, Jankowski, J, Attwood, S
Format: Conference item
Publicat: BioMed Central 2017
Descripció
Sumari:The past two decades have seen dramatic changes in clinical trial conduct and methodology. From trial regulation to data analysis, the rapid rise of randomised control trials (RCTs) has introduced many new techniques. Some methods of designing and conducting RCTs have been widely adopted, whereas other ideas have been used sparingly, despite their promise. Large-scale phase III trials are no different. We present a case study to highlight the changes experienced in designing, setting up, and conducting a large-scale multicentre phase III trial over 14 years.

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