Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

<p>High aerobic glycolytic capacity is correlated with poor prognosis and increased tumour aggressiveness. 6Phosphofructo-1-kinase catalyses the first irreversible step of glycolysis, and is activated by fructose-2,6-bisphosphate, a product of the kinase activity of four bifunctional isoenzyme...

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Bibliografiske detaljer
Hovedforfatter:	Williams, J
Andre forfattere:	Harris, A
Format:	Thesis
Sprog:	English
Udgivet:	2013
Fag:	Organic synthesis Enzymes Tumours Synthetic organic chemistry Metabolism Oncology

Lignende værker

Isoenzyme-specific PFK-2/FBPase-2 Inhibition as an Anti-cancer Strategy
af: Williams, J, et al.
Udgivet: (2012)

Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting
af: Glawar, AFG
Udgivet: (2013)

The synthesis and biological evaluation of novel N-acetylhexosaminidase inhibitors
af: Crabtree, E, et al.
Udgivet: (2011)

Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases
af: Thalhammer, A
Udgivet: (2012)

New methods for nucleophilic fluorination
af: Cresswell, A
Udgivet: (2011)

Stereoselective cyclopropanations of allylic amines and derivatives
af: Ling, K, et al.
Udgivet: (2009)

The synthesis of azetidine and piperidine iminosugars from monosaccharides
af: Lenagh-Snow, G, et al.
Udgivet: (2012)

Selective routes to substituted dihydropyridones
af: Connolly, M, et al.
Udgivet: (2011)

Synthesis of taurospongin A and other biologically active natural products
af: Wu, B
Udgivet: (2017)

Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides: studies towards the syntheses of inthomycin B and inthomycin C
af: Baker, D
Udgivet: (2014)

Rare monosaccharides and biologically active iminosugars from carbohydrate chirons
af: Best, D
Udgivet: (2011)

Methodology for the synthesis of NP25302 and other bioactive natural products
af: Stevens, K
Udgivet: (2011)

Hydrogen-bonding motifs for non-covalent synthesis
af: Pearson, JM
Udgivet: (2013)

Oxidative radical cyclisations for total synthesis
af: Ferrara, S
Udgivet: (2013)

Synthesis of the pyrrolidinone core of oxazolomycin A
af: O'Riordan, TJC
Udgivet: (2009)

Asymmetric synthesis of amino polyols
af: Foster, E
Udgivet: (2012)

The use of functionalised lithium amides in the total synthesis of alkaloids
af: Lee, JA
Udgivet: (2012)

Synthesis studies towards daphlongeranine B
af: Kallstrom, JED
Udgivet: (2013)

Enantioselective synthesis and reactivity of benzylic fluorides
af: Blessley, G, et al.
Udgivet: (2013)

Alkaloids from transannular iodoaminations
af: Brock, E
Udgivet: (2012)

Palladium-catalysed enolate arylation in the synthesis of isoquinolines
af: Gatland, A, et al.
Udgivet: (2014)

Lithiated azetidine and azetine chemistry
af: Pearson, CI
Udgivet: (2014)

Total syntheses of the nakinadine alkaloids
af: Shah, R
Udgivet: (2013)

Cyclisation cascades via reactive iminium intermediates
af: Gregory, AW
Udgivet: (2014)

Rhodium catalysed hydroacylation reactions in the synthesis of heterocycles
af: Ylioja, P
Udgivet: (2011)

Studies towards the stereoselective synthesis of alkenes
af: Arif, T
Udgivet: (2011)

Studies towards the total synthesis of manzamine A
af: Hawkins, A
Udgivet: (2013)

The development of nitro-Mannich/hydroamination cascades for the synthesis of substituted N-heterocycles
af: Barber, D, et al.
Udgivet: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
af: Cordonnier, M, et al.
Udgivet: (2011)

The synthesis and biology of iminosugars and their precursors
af: Ayers, B, et al.
Udgivet: (2014)

The synthesis and applications of cyclic alkenylsiloxanes
af: Elbert, B, et al.
Udgivet: (2014)

Transition metal catalysed C-C bond formation via C-H functionalisation
af: Truscott, FR
Udgivet: (2012)

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
af: Saliba, R, et al.
Udgivet: (2014)

Synthesis of complex γ-lactones mediated by manganese(III)
af: Logan, A
Udgivet: (2012)

Synthesis of the ABC fragment of pectenotoxin-4
af: Lipinski, RM
Udgivet: (2012)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
af: Poingdestre, SJ
Udgivet: (2012)

Aziridinations of tethered allenes
af: Feast, GC
Udgivet: (2011)

Asymmetric synthesis of piperidine alkaloids
af: Thomson, A, et al.
Udgivet: (2012)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
af: Ye, Y
Udgivet: (2013)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
af: Lenden, P
Udgivet: (2011)