Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy
<p>High aerobic glycolytic capacity is correlated with poor prognosis and increased tumour aggressiveness. 6Phosphofructo-1-kinase catalyses the first irreversible step of glycolysis, and is activated by fructose-2,6-bisphosphate, a product of the kinase activity of four bifunctional isoenzyme...
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| Format: | Thèse |
| Langue: | English |
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2013
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