Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations
γ-frequency oscillations (30-120 Hz) in cortical networks influence neuronal encoding and information transfer, and are disrupted in multiple brain disorders. While synaptic inhibition is important for synchronization across the γ-frequency range, the role of distinct interneuronal subtypes in slow...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Society for Neuroscience
2020
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| _version_ | 1797078275695050752 |
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| author | Antonoudiou, P Tan, YL Kontou, G Upton, AL Mann, EO |
| author_facet | Antonoudiou, P Tan, YL Kontou, G Upton, AL Mann, EO |
| author_sort | Antonoudiou, P |
| collection | OXFORD |
| description | γ-frequency oscillations (30-120 Hz) in cortical networks influence neuronal encoding and information transfer, and are disrupted in multiple brain disorders. While synaptic inhibition is important for synchronization across the γ-frequency range, the role of distinct interneuronal subtypes in slow (<60 Hz) and fast γ states remains unclear. Here, we used optogenetics to examine the involvement of parvalbumin-expressing (PV+) and somatostatin-expressing (SST+) interneurons in γ oscillations in the mouse hippocampal CA3 ex vivo, using animals of either sex. Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow γ oscillations. Furthermore, photoexcitation of SST+ interneurons induced fast γ oscillations, which depended on both synaptic excitation and inhibition. Our findings support a critical role for both PV+ and SST+ interneurons in slow hippocampal γ oscillations, and further suggest that intense activation of SST+ interneurons can enable the CA3 circuit to generate fast γ oscillations.
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| first_indexed | 2024-03-07T00:29:47Z |
| format | Journal article |
| id | oxford-uuid:7f609665-5440-42c8-adbb-da8324956514 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:29:47Z |
| publishDate | 2020 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | oxford-uuid:7f609665-5440-42c8-adbb-da83249565142022-03-26T21:16:31ZParvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillationsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7f609665-5440-42c8-adbb-da8324956514EnglishSymplectic ElementsSociety for Neuroscience2020Antonoudiou, PTan, YLKontou, GUpton, ALMann, EOγ-frequency oscillations (30-120 Hz) in cortical networks influence neuronal encoding and information transfer, and are disrupted in multiple brain disorders. While synaptic inhibition is important for synchronization across the γ-frequency range, the role of distinct interneuronal subtypes in slow (<60 Hz) and fast γ states remains unclear. Here, we used optogenetics to examine the involvement of parvalbumin-expressing (PV+) and somatostatin-expressing (SST+) interneurons in γ oscillations in the mouse hippocampal CA3 ex vivo, using animals of either sex. Disrupting either PV+ or SST+ interneuron activity, via either photoinhibition or photoexcitation, led to a decrease in the power of cholinergically induced slow γ oscillations. Furthermore, photoexcitation of SST+ interneurons induced fast γ oscillations, which depended on both synaptic excitation and inhibition. Our findings support a critical role for both PV+ and SST+ interneurons in slow hippocampal γ oscillations, and further suggest that intense activation of SST+ interneurons can enable the CA3 circuit to generate fast γ oscillations. |
| spellingShingle | Antonoudiou, P Tan, YL Kontou, G Upton, AL Mann, EO Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations |
| title | Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations |
| title_full | Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations |
| title_fullStr | Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations |
| title_full_unstemmed | Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations |
| title_short | Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations |
| title_sort | parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations |
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