Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified...

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Bibliographic Details
Main Authors:	Barbeira, A, Dickinson, S, Bonazzola, R, Zheng, J, Wheeler, H, Torres, J, Torstenson, E, Shah, K, Garcia, T, Edwards, T, Stahl, E, Huckins, L, Nicolae, D, Cox, N, Im, H
Format:	Journal article
Published:	Springer Nature 2018

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