Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.

Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.

Upon activation, CD4(+) T cells release cytokines, chemokines, and other soluble factors that influence the kinetics of HIV-1 replication in macrophages (M). In this article, we show that activation of human primary T cells suppresses the early stages of HIV-1 replication in human primary Mφ by down...

書目詳細資料
Main Authors:	Raposo, R, Trudgian, D, Thomas, B, Van Wilgenburg, B, Cowley, S, James, W
格式:	Journal article
語言:	English
出版:	American Association of Immunologists 2011

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