Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation
Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential the...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826281538017296384 |
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| author | Veerapen, N Reddington, F Salio, M Cerundolo, V Besra, G |
| author_facet | Veerapen, N Reddington, F Salio, M Cerundolo, V Besra, G |
| author_sort | Veerapen, N |
| collection | OXFORD |
| description | Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential therapeutic benefits. The length of both the acyl and the sphingosine chains in α-galactosyl ceramides is known to influence the cytokine release profile. We have synthesized analogues of α-GalCer with truncated sphingosine chains for biological evaluation, with particular emphasis on the Th1/Th2 distribution. Starting from a common precursor, d-lyxose, the sphingosine derivatives were synthesised via a straightforward Wittig condensation. © 2010 Elsevier Ltd. All rights reserved. |
| first_indexed | 2024-03-07T00:30:18Z |
| format | Journal article |
| id | oxford-uuid:7f8c8d4a-1ae4-4c63-ac97-91eceffdc3ec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:30:18Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:7f8c8d4a-1ae4-4c63-ac97-91eceffdc3ec2022-03-26T21:17:40ZSynthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7f8c8d4a-1ae4-4c63-ac97-91eceffdc3ecEnglishSymplectic Elements at Oxford2011Veerapen, NReddington, FSalio, MCerundolo, VBesra, GStimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential therapeutic benefits. The length of both the acyl and the sphingosine chains in α-galactosyl ceramides is known to influence the cytokine release profile. We have synthesized analogues of α-GalCer with truncated sphingosine chains for biological evaluation, with particular emphasis on the Th1/Th2 distribution. Starting from a common precursor, d-lyxose, the sphingosine derivatives were synthesised via a straightforward Wittig condensation. © 2010 Elsevier Ltd. All rights reserved. |
| spellingShingle | Veerapen, N Reddington, F Salio, M Cerundolo, V Besra, G Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation |
| title | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation |
| title_full | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation |
| title_fullStr | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation |
| title_full_unstemmed | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation |
| title_short | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation |
| title_sort | synthesis of truncated analogues of the inkt cell agonist α galactosyl ceramide krn7000 and their biological evaluation |
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