Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation

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Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential the...

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Chi tiết về thư mục
Những tác giả chính:	Veerapen, N, Reddington, F, Salio, M, Cerundolo, V, Besra, G
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2011

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