In vivo versus in vitro assays for assessment of T- and B- cell function.

As mice deficient in a particular gene provide an increasing number of novel in vivo models, in vivo assays that examine immune function are becoming a central issue. We found that the sensitivities of in vivo and in vitro assays are strikingly different. These differences have important implication...

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Detalles Bibliográficos
Main Authors: Bachmann, M, Kündig, T
Formato: Journal article
Idioma:English
Publicado: 1994
Descripción
Summary:As mice deficient in a particular gene provide an increasing number of novel in vivo models, in vivo assays that examine immune function are becoming a central issue. We found that the sensitivities of in vivo and in vitro assays are strikingly different. These differences have important implications for the interpretation and biological relevance of results.