Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.

A series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines...

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Main Authors: Moorthy, V, McConkey, S, Roberts, M, Gothard, P, Arulanantham, N, Degano, P, Schneider, J, Hannan, C, Roy, M, Gilbert, S, Peto, T, Hill, A
Formato: Journal article
Idioma:English
Publicado: 2003
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author Moorthy, V
McConkey, S
Roberts, M
Gothard, P
Arulanantham, N
Degano, P
Schneider, J
Hannan, C
Roy, M
Gilbert, S
Peto, T
Hill, A
author_facet Moorthy, V
McConkey, S
Roberts, M
Gothard, P
Arulanantham, N
Degano, P
Schneider, J
Hannan, C
Roy, M
Gilbert, S
Peto, T
Hill, A
author_sort Moorthy, V
collection OXFORD
description A series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines alone or in DNA/MVA prime-boost combinations. The DNA vaccine was administered either intramuscularly by needle or intradermally by a needleless delivery device. The MVA vaccine was administered intradermally by needle. The vaccines were well-tolerated by all three routes and in various DNA/MVA immunisation regimes. There were no severe or serious adverse events.
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spelling oxford-uuid:7f98766a-7340-4b6c-ad4c-f3d1ba3ed1d42022-03-26T21:17:57ZSafety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7f98766a-7340-4b6c-ad4c-f3d1ba3ed1d4EnglishSymplectic Elements at Oxford2003Moorthy, VMcConkey, SRoberts, MGothard, PArulanantham, NDegano, PSchneider, JHannan, CRoy, MGilbert, SPeto, THill, AA series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines alone or in DNA/MVA prime-boost combinations. The DNA vaccine was administered either intramuscularly by needle or intradermally by a needleless delivery device. The MVA vaccine was administered intradermally by needle. The vaccines were well-tolerated by all three routes and in various DNA/MVA immunisation regimes. There were no severe or serious adverse events.
spellingShingle Moorthy, V
McConkey, S
Roberts, M
Gothard, P
Arulanantham, N
Degano, P
Schneider, J
Hannan, C
Roy, M
Gilbert, S
Peto, T
Hill, A
Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
title Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
title_full Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
title_fullStr Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
title_full_unstemmed Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
title_short Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
title_sort safety of dna and modified vaccinia virus ankara vaccines against liver stage p falciparum malaria in non immune volunteers
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