Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.
A series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2003
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| _version_ | 1826281546629251072 |
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| author | Moorthy, V McConkey, S Roberts, M Gothard, P Arulanantham, N Degano, P Schneider, J Hannan, C Roy, M Gilbert, S Peto, T Hill, A |
| author_facet | Moorthy, V McConkey, S Roberts, M Gothard, P Arulanantham, N Degano, P Schneider, J Hannan, C Roy, M Gilbert, S Peto, T Hill, A |
| author_sort | Moorthy, V |
| collection | OXFORD |
| description | A series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines alone or in DNA/MVA prime-boost combinations. The DNA vaccine was administered either intramuscularly by needle or intradermally by a needleless delivery device. The MVA vaccine was administered intradermally by needle. The vaccines were well-tolerated by all three routes and in various DNA/MVA immunisation regimes. There were no severe or serious adverse events. |
| first_indexed | 2024-03-07T00:30:26Z |
| format | Journal article |
| id | oxford-uuid:7f98766a-7340-4b6c-ad4c-f3d1ba3ed1d4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:30:26Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:7f98766a-7340-4b6c-ad4c-f3d1ba3ed1d42022-03-26T21:17:57ZSafety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7f98766a-7340-4b6c-ad4c-f3d1ba3ed1d4EnglishSymplectic Elements at Oxford2003Moorthy, VMcConkey, SRoberts, MGothard, PArulanantham, NDegano, PSchneider, JHannan, CRoy, MGilbert, SPeto, THill, AA series of phase I clinical studies were conducted to evaluate the safety of plasmid DNA and modified vaccinia virus Ankara malaria vaccines. The vaccines each encoded a polyepitope string fused to whole Plasmodium falciparum TRAP antigen. Forty-three healthy adult volunteers received the vaccines alone or in DNA/MVA prime-boost combinations. The DNA vaccine was administered either intramuscularly by needle or intradermally by a needleless delivery device. The MVA vaccine was administered intradermally by needle. The vaccines were well-tolerated by all three routes and in various DNA/MVA immunisation regimes. There were no severe or serious adverse events. |
| spellingShingle | Moorthy, V McConkey, S Roberts, M Gothard, P Arulanantham, N Degano, P Schneider, J Hannan, C Roy, M Gilbert, S Peto, T Hill, A Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. |
| title | Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. |
| title_full | Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. |
| title_fullStr | Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. |
| title_full_unstemmed | Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. |
| title_short | Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. |
| title_sort | safety of dna and modified vaccinia virus ankara vaccines against liver stage p falciparum malaria in non immune volunteers |
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