Insulin signalling regulates remating in female Drosophila.
Mating rate is a major determinant of female lifespan and fitness, and is predicted to optimize at an intermediate level, beyond which superfluous matings are costly. In female Drosophila melanogaster, nutrition is a key regulator of mating rate but the underlying mechanism is unknown. The evolution...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society
2010
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| _version_ | 1797078328002215936 |
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| author | Wigby, S Slack, C Grönke, S Martinez, P Calboli, F Chapman, T Partridge, L |
| author_facet | Wigby, S Slack, C Grönke, S Martinez, P Calboli, F Chapman, T Partridge, L |
| author_sort | Wigby, S |
| collection | OXFORD |
| description | Mating rate is a major determinant of female lifespan and fitness, and is predicted to optimize at an intermediate level, beyond which superfluous matings are costly. In female Drosophila melanogaster, nutrition is a key regulator of mating rate but the underlying mechanism is unknown. The evolutionarily conserved insulin/insulin-like growth factor-like signalling (IIS) pathway is responsive to nutrition, and regulates development, metabolism, stress resistance, fecundity and lifespan. Here we show that inhibition of IIS, by ablation of Drosophila insulin-like peptide (DILP)-producing median neurosecretory cells, knockout of dilp2, dilp3 or dilp5 genes, expression of a dominant-negative DILP-receptor (InR) transgene or knockout of Lnk, results in reduced female remating rates. IIS-mediated regulation of female remating can occur independent of virgin receptivity, developmental defects, reduced body size or fecundity, and the receipt of the female receptivity-inhibiting male sex peptide. Our results provide a likely mechanism by which females match remating rates to the perceived nutritional environment. The findings suggest that longevity-mediating genes could often have pleiotropic effects on remating rate. However, overexpression of the IIS-regulated transcription factor dFOXO in the fat body-which extends lifespan-does not affect remating rate. Thus, long life and reduced remating are not obligatorily coupled. |
| first_indexed | 2024-03-07T00:30:30Z |
| format | Journal article |
| id | oxford-uuid:7f9f6fb3-1899-4ff0-a843-ececd270e593 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:30:30Z |
| publishDate | 2010 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:7f9f6fb3-1899-4ff0-a843-ececd270e5932022-03-26T21:18:07ZInsulin signalling regulates remating in female Drosophila.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7f9f6fb3-1899-4ff0-a843-ececd270e593EnglishSymplectic Elements at OxfordRoyal Society2010Wigby, SSlack, CGrönke, SMartinez, PCalboli, FChapman, TPartridge, LMating rate is a major determinant of female lifespan and fitness, and is predicted to optimize at an intermediate level, beyond which superfluous matings are costly. In female Drosophila melanogaster, nutrition is a key regulator of mating rate but the underlying mechanism is unknown. The evolutionarily conserved insulin/insulin-like growth factor-like signalling (IIS) pathway is responsive to nutrition, and regulates development, metabolism, stress resistance, fecundity and lifespan. Here we show that inhibition of IIS, by ablation of Drosophila insulin-like peptide (DILP)-producing median neurosecretory cells, knockout of dilp2, dilp3 or dilp5 genes, expression of a dominant-negative DILP-receptor (InR) transgene or knockout of Lnk, results in reduced female remating rates. IIS-mediated regulation of female remating can occur independent of virgin receptivity, developmental defects, reduced body size or fecundity, and the receipt of the female receptivity-inhibiting male sex peptide. Our results provide a likely mechanism by which females match remating rates to the perceived nutritional environment. The findings suggest that longevity-mediating genes could often have pleiotropic effects on remating rate. However, overexpression of the IIS-regulated transcription factor dFOXO in the fat body-which extends lifespan-does not affect remating rate. Thus, long life and reduced remating are not obligatorily coupled. |
| spellingShingle | Wigby, S Slack, C Grönke, S Martinez, P Calboli, F Chapman, T Partridge, L Insulin signalling regulates remating in female Drosophila. |
| title | Insulin signalling regulates remating in female Drosophila. |
| title_full | Insulin signalling regulates remating in female Drosophila. |
| title_fullStr | Insulin signalling regulates remating in female Drosophila. |
| title_full_unstemmed | Insulin signalling regulates remating in female Drosophila. |
| title_short | Insulin signalling regulates remating in female Drosophila. |
| title_sort | insulin signalling regulates remating in female drosophila |
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