Plasmodium vivax susceptibility to ferroquine.
The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inh...
| Autores principales: | , , , , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2010
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| _version_ | 1826281556759543808 |
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| author | Leimanis, M Jaidee, A Sriprawat, K Kaewpongsri, S Suwanarusk, R Barends, M Phyo, A Russell, B Renia, L Nosten, F |
| author_facet | Leimanis, M Jaidee, A Sriprawat, K Kaewpongsri, S Suwanarusk, R Barends, M Phyo, A Russell, B Renia, L Nosten, F |
| author_sort | Leimanis, M |
| collection | OXFORD |
| description | The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria. |
| first_indexed | 2024-03-07T00:30:35Z |
| format | Journal article |
| id | oxford-uuid:7fa73f04-4b3f-4299-8ec1-69368b7e3828 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:30:35Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:7fa73f04-4b3f-4299-8ec1-69368b7e38282022-03-26T21:18:18ZPlasmodium vivax susceptibility to ferroquine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7fa73f04-4b3f-4299-8ec1-69368b7e3828EnglishSymplectic Elements at Oxford2010Leimanis, MJaidee, ASriprawat, KKaewpongsri, SSuwanarusk, RBarends, MPhyo, ARussell, BRenia, LNosten, FThe novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria. |
| spellingShingle | Leimanis, M Jaidee, A Sriprawat, K Kaewpongsri, S Suwanarusk, R Barends, M Phyo, A Russell, B Renia, L Nosten, F Plasmodium vivax susceptibility to ferroquine. |
| title | Plasmodium vivax susceptibility to ferroquine. |
| title_full | Plasmodium vivax susceptibility to ferroquine. |
| title_fullStr | Plasmodium vivax susceptibility to ferroquine. |
| title_full_unstemmed | Plasmodium vivax susceptibility to ferroquine. |
| title_short | Plasmodium vivax susceptibility to ferroquine. |
| title_sort | plasmodium vivax susceptibility to ferroquine |
| work_keys_str_mv | AT leimanism plasmodiumvivaxsusceptibilitytoferroquine AT jaideea plasmodiumvivaxsusceptibilitytoferroquine AT sriprawatk plasmodiumvivaxsusceptibilitytoferroquine AT kaewpongsris plasmodiumvivaxsusceptibilitytoferroquine AT suwanaruskr plasmodiumvivaxsusceptibilitytoferroquine AT barendsm plasmodiumvivaxsusceptibilitytoferroquine AT phyoa plasmodiumvivaxsusceptibilitytoferroquine AT russellb plasmodiumvivaxsusceptibilitytoferroquine AT renial plasmodiumvivaxsusceptibilitytoferroquine AT nostenf plasmodiumvivaxsusceptibilitytoferroquine |