Single‐molecule observation of intermediates in bioorthogonal 2‐cyanobenzothiazole chemistry
We report a single‐molecule mechanistic investigation into 2‐cyanobenzothiazole (CBT) chemistry within a protein nanoreactor. When simple thiols reacted reversibly with CBT, the thioimidate monoadduct was approximately 80‐fold longer‐lived than the tetrahedral bisadduct, with important implications...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2020
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Single‐molecule observation of intermediates in bioorthogonal 2‐cyanobenzothiazole chemistry
Published 2020
Journal article