Citric acid cycle intermediates in cardioprotection.
Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic appr...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1797078377996222464 |
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| author | Czibik, G Steeples, V Yavari, A Ashrafian, H |
| author_facet | Czibik, G Steeples, V Yavari, A Ashrafian, H |
| author_sort | Czibik, G |
| collection | OXFORD |
| description | Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved in cardioprotection. Inspired by cross-fertilization between fundamental cancer biology and cardiovascular medicine, a set of metabolic observations have identified novel metabolic pathways, easily manipulable in man, which can harness metabolism to robustly combat ischemia-reperfusion injury. |
| first_indexed | 2024-03-07T00:31:06Z |
| format | Journal article |
| id | oxford-uuid:7fd44855-147b-4d6d-a5d6-b135a3e3d930 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:31:06Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:7fd44855-147b-4d6d-a5d6-b135a3e3d9302022-03-26T21:19:20ZCitric acid cycle intermediates in cardioprotection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7fd44855-147b-4d6d-a5d6-b135a3e3d930EnglishSymplectic Elements at Oxford2014Czibik, GSteeples, VYavari, AAshrafian, HOver the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved in cardioprotection. Inspired by cross-fertilization between fundamental cancer biology and cardiovascular medicine, a set of metabolic observations have identified novel metabolic pathways, easily manipulable in man, which can harness metabolism to robustly combat ischemia-reperfusion injury. |
| spellingShingle | Czibik, G Steeples, V Yavari, A Ashrafian, H Citric acid cycle intermediates in cardioprotection. |
| title | Citric acid cycle intermediates in cardioprotection. |
| title_full | Citric acid cycle intermediates in cardioprotection. |
| title_fullStr | Citric acid cycle intermediates in cardioprotection. |
| title_full_unstemmed | Citric acid cycle intermediates in cardioprotection. |
| title_short | Citric acid cycle intermediates in cardioprotection. |
| title_sort | citric acid cycle intermediates in cardioprotection |
| work_keys_str_mv | AT czibikg citricacidcycleintermediatesincardioprotection AT steeplesv citricacidcycleintermediatesincardioprotection AT yavaria citricacidcycleintermediatesincardioprotection AT ashrafianh citricacidcycleintermediatesincardioprotection |