Elevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infection
<p>Background: It is unclear whether antibodies can prevent Mycobacterium tuberculosis (Mtb) infection. In this study, we examined the relationship between total plasma IgG levels, IgG elicited by childhood vaccines and soil-transmitted helminths, and Mtb infection prevalence, defined by posit...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Frontiers Media
2018
|
| _version_ | 1826281599465947136 |
|---|---|
| author | Logan, E Luabeya, A Mulenga, H Mrdjen, D Ontong, C Cunningham, A Tameris, M McShane, H Scriba, T Horsnell, W Hatherill, M |
| author_facet | Logan, E Luabeya, A Mulenga, H Mrdjen, D Ontong, C Cunningham, A Tameris, M McShane, H Scriba, T Horsnell, W Hatherill, M |
| author_sort | Logan, E |
| collection | OXFORD |
| description | <p>Background: It is unclear whether antibodies can prevent Mycobacterium tuberculosis (Mtb) infection. In this study, we examined the relationship between total plasma IgG levels, IgG elicited by childhood vaccines and soil-transmitted helminths, and Mtb infection prevalence, defined by positive QuantiFERON (QFT) test.</p><p> Methods: We studied 100 Mtb uninfected infants, aged 4–6 months. Ten infants (10%) converted to positive QFT test (QFT+) within 2 years of follow-up for Mtb infection. Antibody responses in plasma samples acquired at baseline and tuberculosis investigation were analyzed by enzyme-linked immunosorbent assay and ImmunoCAP® assay.</p><p> Results: QFT− infants displayed a significant increase in total IgG titers when re-tested, compared to IgG titers at baseline, which was not observed in QFT+ infants. Bacille Calmette-Guérin (BCG) vaccine-specific IgG2 and live-attenuated measles vaccine-specific IgG were raised in QFT− infants, and infants who acquired an Mtb infection did not appear to launch a BCG-specific IgG2 response. IgG titers against the endemic helminth Ascaris lumbricoides increased from baseline to QFT re-testing in all infants.</p><p> Conclusion: These data show raised IgG associates with a QFT-status. Importantly, this effect was also associated with a trend showing raised IgG titers to BCG and measles vaccine. Our data suggest a possible protective association between raised antibody titers and acquisition of Mtb infection, potentially mediated by exposure to antigens both related and unrelated to Mtb.</p> |
| first_indexed | 2024-03-07T00:31:13Z |
| format | Journal article |
| id | oxford-uuid:7fdd5406-faad-467e-8ff7-4313ba245399 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:31:13Z |
| publishDate | 2018 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:7fdd5406-faad-467e-8ff7-4313ba2453992022-03-26T21:19:39ZElevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infectionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7fdd5406-faad-467e-8ff7-4313ba245399EnglishSymplectic Elements at OxfordFrontiers Media2018Logan, ELuabeya, AMulenga, HMrdjen, DOntong, CCunningham, ATameris, MMcShane, HScriba, THorsnell, WHatherill, M<p>Background: It is unclear whether antibodies can prevent Mycobacterium tuberculosis (Mtb) infection. In this study, we examined the relationship between total plasma IgG levels, IgG elicited by childhood vaccines and soil-transmitted helminths, and Mtb infection prevalence, defined by positive QuantiFERON (QFT) test.</p><p> Methods: We studied 100 Mtb uninfected infants, aged 4–6 months. Ten infants (10%) converted to positive QFT test (QFT+) within 2 years of follow-up for Mtb infection. Antibody responses in plasma samples acquired at baseline and tuberculosis investigation were analyzed by enzyme-linked immunosorbent assay and ImmunoCAP® assay.</p><p> Results: QFT− infants displayed a significant increase in total IgG titers when re-tested, compared to IgG titers at baseline, which was not observed in QFT+ infants. Bacille Calmette-Guérin (BCG) vaccine-specific IgG2 and live-attenuated measles vaccine-specific IgG were raised in QFT− infants, and infants who acquired an Mtb infection did not appear to launch a BCG-specific IgG2 response. IgG titers against the endemic helminth Ascaris lumbricoides increased from baseline to QFT re-testing in all infants.</p><p> Conclusion: These data show raised IgG associates with a QFT-status. Importantly, this effect was also associated with a trend showing raised IgG titers to BCG and measles vaccine. Our data suggest a possible protective association between raised antibody titers and acquisition of Mtb infection, potentially mediated by exposure to antigens both related and unrelated to Mtb.</p> |
| spellingShingle | Logan, E Luabeya, A Mulenga, H Mrdjen, D Ontong, C Cunningham, A Tameris, M McShane, H Scriba, T Horsnell, W Hatherill, M Elevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infection |
| title | Elevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infection |
| title_full | Elevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infection |
| title_fullStr | Elevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infection |
| title_full_unstemmed | Elevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infection |
| title_short | Elevated IgG responses in infants are associated with reduced prevalence of Mycobacterium tuberculosis infection |
| title_sort | elevated igg responses in infants are associated with reduced prevalence of mycobacterium tuberculosis infection |
| work_keys_str_mv | AT logane elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT luabeyaa elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT mulengah elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT mrdjend elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT ontongc elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT cunninghama elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT tamerism elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT mcshaneh elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT scribat elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT horsnellw elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection AT hatherillm elevatediggresponsesininfantsareassociatedwithreducedprevalenceofmycobacteriumtuberculosisinfection |