Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome.

Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome.

Muenke syndrome, defined by heterozygosity for a Pro250Arg substitution in fibroblast growth factor receptor 3 (FGFR3), is the most common genetic cause of craniosynostosis in humans. We have used gene targeting to introduce the Muenke syndrome mutation (equivalent to P244R) into the murine Fgfr3 ge...

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Bibliographic Details
Main Authors: Twigg, SR, Healy, C, Babbs, C, Sharpe, J, Wood, W, Sharpe, P, Morriss-Kay, G, Wilkie, A
Format: Journal article
Language:English
Published: 2009

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