Synthesis of (-)-(Z)-deoxypukalide.
(Chemical Equation Presented) Closing the deal: A ring-closing metathesis (RCM)/aromatization protocol, followed by a regioselective Negishi cross-coupling reaction and macrolactonization, with subsequent RCM mediate the synthesis of (-)-(Z)-deoxypukalide in 12 linear steps and 15% overall yield (se...
| Autors principals: | , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2008
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| Sumari: | (Chemical Equation Presented) Closing the deal: A ring-closing metathesis (RCM)/aromatization protocol, followed by a regioselective Negishi cross-coupling reaction and macrolactonization, with subsequent RCM mediate the synthesis of (-)-(Z)-deoxypukalide in 12 linear steps and 15% overall yield (see retrosynthesis; TBS=tert-butyldimethylsilyl, TIPS=triisopropylsilyl). © 2008 Wiley-VCH Verlag GmbH and Co. KGaA. |
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