Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy.
Improving the efficacy of standard chemotherapy by targeting DNA repair mechanisms remains an important area of research. O6-methylguanine-DNA-methyltransferase (MGMT), which repairs alkylating agent damage, is one such target. Downregulation of the gene through epigenetic silencing has been shown t...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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