Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-D-galactonate - a novel class of carbopeptoid-cyclodextrin (CPCD)

Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-D-galactonate - a novel class of carbopeptoid-cyclodextrin (CPCD)

Circular dichroism studies on a series of linear oligomers derived from a protected 6-amino-6-deoxy-D-galactonate (an ε-amino acid) indicated a predisposition to form a rigid structure in solution, which is comparable to a β-sheet composed of L-amino acids; in contrast, a diastereomeric allonate ser...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Mayes, B, Stetz, R, Watterson, M, Edwards, A, Ansell, C, Tranter, G, Fleet, G
التنسيق: Journal article
اللغة:English
منشور في: 2004
الوصف
الملخص:Circular dichroism studies on a series of linear oligomers derived from a protected 6-amino-6-deoxy-D-galactonate (an ε-amino acid) indicated a predisposition to form a rigid structure in solution, which is comparable to a β-sheet composed of L-amino acids; in contrast, a diastereomeric allonate series provided no evidence for secondary structure. A linear tetramer was cyclised to a 28-membered ring lactam in modest yield, which on deprotection formed a class of macrocycle with structural features of both a cyclic peptide and a cyclodextrin. © 2004 Elsevier Ltd. All rights reserved.

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