The respiratory functions of blood
<p>Current views on the nature of the haemoglobin-oxygen equilibria have been reviewed and the need for improved experimental techniques stated. A multiple-addition mixing technique for investigation of the equilibria, together with the neccessary ancillary techni...
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| Format: | Thesis |
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1970
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| Summary: | <p>Current views on the nature of the haemoglobin-oxygen equilibria have been reviewed and the need for improved experimental techniques stated. A multiple-addition mixing technique for investigation of the equilibria, together with the neccessary ancillary techniques, has been developed and an exhaustive mathematical analysis of the results, using a specially written computer programme, described. A detailed validation of the techniques has been carried out and their particular advantages and disadvantages compared with other techniques.</p> <p>The multiple-addition mixing technique has been used to investigate the effects of pH on the parameters of some of the more important models for the haemoglobin- oxygen equilibria and the results compared with those predicted from theoretical considerations.</p> <p>None of the models considered emerged as a complete description of the data obtained and guidelines for the development of new models have been given.</p> |
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