A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk.

OBJECTIVE: Increased levels of lipoprotein(a) are a highly heritable risk factor for coronary artery disease (CAD). The genetic determinants of lipoprotein(a) levels are mainly because of genetic variation in the apolipoprotein(a) gene (LPA). We have tested the association of a relatively common nul...

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Autori principali: Kyriakou, T, Seedorf, U, Goel, A, Hopewell, J, Clarke, R, Watkins, H, Farrall, M
Natura: Journal article
Lingua:English
Pubblicazione: 2014

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