A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.
TrkB is a member of the Trk family of tyrosine kinase receptors. In vivo, the extracellular region of TrkB is known to bind, with high affinity, the neurotrophin protein brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). We describe the expression and purification of the second Ig-l...
المؤلفون الرئيسيون: | Naylor, R, Robertson, A, Allen, S, Sessions, R, Clarke, A, Mason, G, Burston, J, Tyler, S, Wilcock, G, Dawbarn, D |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2002
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مواد مشابهة
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Structure of TrkAIg2 and molecular modelling of the neurotrophin binding sites of the Trk receptors
حسب: Robertson, A, وآخرون
منشور في: (2000) -
Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease.
حسب: Allen, S, وآخرون
منشور في: (1999) -
Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.
حسب: Allen, S, وآخرون
منشور في: (1994) -
Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
حسب: Holden, P, وآخرون
منشور في: (1997) -
Identification and structure of the nerve growth factor binding site on TrkA.
حسب: Robertson, A, وآخرون
منشور في: (2001)