A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.
TrkB is a member of the Trk family of tyrosine kinase receptors. In vivo, the extracellular region of TrkB is known to bind, with high affinity, the neurotrophin protein brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). We describe the expression and purification of the second Ig-l...
Prif Awduron: | Naylor, R, Robertson, A, Allen, S, Sessions, R, Clarke, A, Mason, G, Burston, J, Tyler, S, Wilcock, G, Dawbarn, D |
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Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
2002
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Eitemau Tebyg
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Structure of TrkAIg2 and molecular modelling of the neurotrophin binding sites of the Trk receptors
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