A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.
TrkB is a member of the Trk family of tyrosine kinase receptors. In vivo, the extracellular region of TrkB is known to bind, with high affinity, the neurotrophin protein brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). We describe the expression and purification of the second Ig-l...
Huvudupphovsmän: | Naylor, R, Robertson, A, Allen, S, Sessions, R, Clarke, A, Mason, G, Burston, J, Tyler, S, Wilcock, G, Dawbarn, D |
---|---|
Materialtyp: | Journal article |
Språk: | English |
Publicerad: |
2002
|
Liknande verk
Liknande verk
-
Structure of TrkAIg2 and molecular modelling of the neurotrophin binding sites of the Trk receptors
av: Robertson, A, et al.
Publicerad: (2000) -
Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease.
av: Allen, S, et al.
Publicerad: (1999) -
Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.
av: Allen, S, et al.
Publicerad: (1994) -
Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
av: Holden, P, et al.
Publicerad: (1997) -
Identification and structure of the nerve growth factor binding site on TrkA.
av: Robertson, A, et al.
Publicerad: (2001)