NMR study of the structure and dynamics of the BRCT domain from the kinetochore protein KKT4

KKT4 is a multi-domain kinetochore protein specific to kinetoplastids, such as Trypanosoma brucei. It lacks significant sequence similarity to known kinetochore proteins in other eukaryotes. Our recent X-ray structure of the C-terminal region of KKT4 shows that it has a tandem BRCT (BRCA1 C Terminus...

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Bibliographic Details
Main Authors: Ludzia, P, Hayashi, H, Robinson, T, Akiyoshi, B, Redfield, C
Format: Journal article
Language:English
Published: Springer 2024