Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.

BACKGROUND: Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (<2%) of its variation. METHODS AND RE...

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Hlavní autoři:	Sabater-Lleal, M, Huang, J, Chasman, D, Naitza, S, Dehghan, A, Johnson, A, Teumer, A, Reiner, A, Folkersen, L, Basu, S, Rudnicka, A, Trompet, S, Mälarstig, A, Baumert, J, Bis, J, Guo, X, Hottenga, J, Shin, S, Lopez, L, Lahti, J, Tanaka, T, Yanek, L, Oudot-Mellakh, T, Wilson, J, Navarro, P
Médium:	Journal article
Jazyk:	English
Vydáno:	2013

Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.

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Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.