Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network study
<br><strong>Background: </strong>Antihypertensive drugs (AHTs), especially calcium channel blockers (CCBs), have been associated with differential rates of a number of neuropsychiatric outcomes. Delirium is commonly attributed to medication, including AHTs, but delirium incidence h...
| Main Authors: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
SAGE Publications
2020
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| _version_ | 1826281758063067136 |
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| author | Harrison, P Luciano, S Colbourne, L |
| author_facet | Harrison, P Luciano, S Colbourne, L |
| author_sort | Harrison, P |
| collection | OXFORD |
| description | <br><strong>Background: </strong>Antihypertensive drugs (AHTs), especially calcium channel blockers (CCBs), have been associated with differential rates of a number of neuropsychiatric outcomes. Delirium is commonly attributed to medication, including AHTs, but delirium incidence has not been compared directly between AHT classes.</br>
<br><strong>Methods: </strong>Using a federated electronic health records network of 25.5 million people aged 50 years or older, we measured rates of delirium over a 2-year period in patients prescribed CCBs compared to the other main AHT classes. Extensive propensity score matching was used to create cohorts matched for a range of demographic factors and delirium risk factors. Negative control outcomes were also measured.</br>
<br><strong>Results: </strong>Cohort sizes ranged from 54,000 to 577,000. Delirium was more common with CCBs than with renin-angiotensin system (RAS) agents (~40% higher) but less common than with beta-blockers (~20% lower). These differences remained when patients with a range of other delirium risk factors were excluded, and they were not paralleled by the negative control outcomes. Comparisons between CCBs and diuretics produced inconclusive results.</br>
<br><strong>Conclusions: </strong>CCBs are associated with higher rates of delirium than RAS agents, but lower rates compared to beta-blockers. The findings add to the list of factors which may be considered when choosing AHT class.</br>
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| first_indexed | 2024-03-07T00:33:37Z |
| format | Journal article |
| id | oxford-uuid:80a97657-1927-4f1e-a6fc-4e36aad4b446 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:33:37Z |
| publishDate | 2020 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:80a97657-1927-4f1e-a6fc-4e36aad4b4462022-03-26T21:24:51ZRates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:80a97657-1927-4f1e-a6fc-4e36aad4b446EnglishSymplectic ElementsSAGE Publications2020Harrison, PLuciano, SColbourne, L<br><strong>Background: </strong>Antihypertensive drugs (AHTs), especially calcium channel blockers (CCBs), have been associated with differential rates of a number of neuropsychiatric outcomes. Delirium is commonly attributed to medication, including AHTs, but delirium incidence has not been compared directly between AHT classes.</br> <br><strong>Methods: </strong>Using a federated electronic health records network of 25.5 million people aged 50 years or older, we measured rates of delirium over a 2-year period in patients prescribed CCBs compared to the other main AHT classes. Extensive propensity score matching was used to create cohorts matched for a range of demographic factors and delirium risk factors. Negative control outcomes were also measured.</br> <br><strong>Results: </strong>Cohort sizes ranged from 54,000 to 577,000. Delirium was more common with CCBs than with renin-angiotensin system (RAS) agents (~40% higher) but less common than with beta-blockers (~20% lower). These differences remained when patients with a range of other delirium risk factors were excluded, and they were not paralleled by the negative control outcomes. Comparisons between CCBs and diuretics produced inconclusive results.</br> <br><strong>Conclusions: </strong>CCBs are associated with higher rates of delirium than RAS agents, but lower rates compared to beta-blockers. The findings add to the list of factors which may be considered when choosing AHT class.</br> |
| spellingShingle | Harrison, P Luciano, S Colbourne, L Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network study |
| title | Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network study |
| title_full | Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network study |
| title_fullStr | Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network study |
| title_full_unstemmed | Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network study |
| title_short | Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents, and beta-blockers: an electronic health records network study |
| title_sort | rates of delirium associated with calcium channel blockers compared to diuretics renin angiotensin system agents and beta blockers an electronic health records network study |
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