Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

GAK (cyclin G-associated kinase) is a key regulator of clathrin-coated vesicle trafficking and plays a central role during development. Additionally, due to the unusually high plasticity of its catalytic domain, it is a frequent 'off-target' of clinical kinase inhibitors associated with re...

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Bibliographic Details
Main Authors: Chaikuad, A, Keates, T, Vincke, C, Kaufholz, M, Zenn, M, Zimmermann, B, Gutiérrez, C, Zhang, R, Hatzos-Skintges, C, Joachimiak, A, Muyldermans, S, Herberg, F, Knapp, S, Müller, S
Format: Journal article
Language:English
Published: Portland Press Ltd 2014

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