Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria.

Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria.

Lactic acidosis frequently complicates severe malaria in African children, and is a strong independent predictor of mortality. We tested the hypothesis that sodium dichloroacetate (DCA), an activator of pyruvate dehydrogenase, rapidly reduces hyperlactataemia in this patient population. Eighteen chi...

书目详细资料
Main Authors:	Krishna, S, Agbenyega, T, Angus, B, Bedu-Addo, G, Ofori-Amanfo, G, Henderson, G, Szwandt, I, O'Brien, R, Stacpoole, P
格式:	Journal article
语言:	English
出版:	1995

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