Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains

Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains

Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we describe a dual inhibitor of the bromodomain and PHD finger (BRPF) family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L. These proteins are foun...

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Detalhes bibliográficos
Main Authors: Bouché, L, Christ, C, Siegel, S, Fernández-Montalván, A, Holton, S, Fedorov, O, Ter Laak, A, Sugawara, T, Stöckigt, D, Tallant, C, Bennett, J, Monteiro, O, Díaz-Sáez, L, Siejka, P, Meier, J, Pütter, V, Weiske, J, Müller, S, Huber, K, Hartung, I, Haendler, B
Formato: Journal article
Idioma:English
Publicado em: American Chemical Society 2017

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