Proteins of the penicillin biosynthesis pathway.

Two sequential steps are common to the biosynthesis of all penicillin-derived antibiotics: the reaction of three L-amino acids to give L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine, and the oxidation of this tripeptide to give isopenicillin N. Recent studies on the peptide synthetase and oxidase...

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Bibliographic Details
Main Authors: Schofield, C, Baldwin, J, Byford, M, Clifton, I, Hajdu, J, Hensgens, C, Roach, P
Format: Journal article
Language:English
Published: 1997