Proteins of the penicillin biosynthesis pathway.
Two sequential steps are common to the biosynthesis of all penicillin-derived antibiotics: the reaction of three L-amino acids to give L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine, and the oxidation of this tripeptide to give isopenicillin N. Recent studies on the peptide synthetase and oxidase...
Main Authors: | Schofield, C, Baldwin, J, Byford, M, Clifton, I, Hajdu, J, Hensgens, C, Roach, P |
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Format: | Journal article |
Language: | English |
Published: |
1997
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