B-11 NMR-STUDIES OF AN ARYL BORONIC ACID BOUND TO CHYMOTRYPSIN AND SUBTILISIN

The binding of aryl boronic acids to α-chymotrypsin and subtilisin has been studied by 11B NMR spectroscopy; evidence is provided for the direct spectroscopic observation of a tetrahedral enzyme/boromate complex. © 1991.

Bibliographische Detailangaben
Hauptverfasser:	Baldwin, J, Claridge, T, Derome, A, Schofield, C, Smith, B
Format:	Journal article
Sprache:	English
Veröffentlicht:	1991

Ähnliche Einträge

DIRECT OBSERVATION OF A TETRAHEDRAL BORONIC ACID BETA-LACTAMASE COMPLEX USING B-11 NMR-SPECTROSCOPY
von: Baldwin, J, et al.
Veröffentlicht: (1991)

Crystal structure of an intracellular subtilisin reveals novel structural features unique to this subtilisin family
von: Vévodová, J, et al.
Veröffentlicht: (2010)

Subtilisin structure and catalysis in non-aqueous media
von: Schmitke, Jennifer L. (Jennifer Louise), 1971-
Veröffentlicht: (2010)

Developments in the characterisation of the catalytic triad of alpha-chymotrypsin: Effect of the protonation state of Asp102 on the 1H NMR signals of His57.
von: Bruylants, G, et al.
Veröffentlicht: (2007)

The controlled introduction of multiple negative charge at single amino acid sites in subtilisin Bacillus lentus.
von: Davis, B, et al.
Veröffentlicht: (1999)

Versatility of subtilisin: a review on structure, characteristics, and applications
von: Mohd Azrin, Nur Aliyah, et al.
Veröffentlicht: (2022)

Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride
von: Zhao, Q, et al.
Veröffentlicht: (2020)

Altering the specificity of subtilisin Bacillus lentus through the introduction of positive charge at single amino acid sites.
von: Davis, B, et al.
Veröffentlicht: (1999)

Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments.
von: Cai, J, et al.
Veröffentlicht: (2009)

EQUIPMENT FOR SELECTIVE EXCITATION IN NMR-SPECTROSCOPY - ENHANCED TECHNIQUES FOR RADIOFREQUENCY MODULATION AND DIGITAL PULSE-SHAPE GENERATION
von: Gregory, N, et al.
Veröffentlicht: (1994)

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
von: Demetriades, M, et al.
Veröffentlicht: (2012)

Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride
von: Sap, J, et al.
Veröffentlicht: (2019)

Enantioselective three-component assembly of β’-aryl-enones using a rhodium-catalyzed alkyne hydroacylation/aryl boronic acid conjugate addition sequence
von: Gao, M, et al.
Veröffentlicht: (2017)

Protonation linked equilibria and apparent affinity constants: the thermodynamic profile of the alpha-chymotrypsin-proflavin interaction.
von: Bruylants, G, et al.
Veröffentlicht: (2007)

Nickel(II)-catalyzed synthesis of sulfinates from aryl and heteroaryl boronic acids and the sulfur dioxide surrogate DABSO
von: Willis, M, et al.
Veröffentlicht: (2019)

NMR studies of boron hydrides and related compounds /
von: 241690 Eaton, Garenth R., et al.
Veröffentlicht: (1969)

Activities of amylase, trypsin and chymotrypsin of pancreas and small intestinal contents in the red jungle fowl and broiler breed
von: Kadhim, Khalid Kamil, et al.
Veröffentlicht: (2011)

Site-selective glycosylation of subtilisin Bacillus lentus causes dramatic increases in esterase activity.
von: Lloyd, R, et al.
Veröffentlicht: (2000)

Carbon-carbon bond construction using boronic acids and aryl methyl sulfides: orthogonal reactivity in Suzuki-type couplings
von: Hooper, J, et al.
Veröffentlicht: (2013)

An approach to enzyme inhibition employing reversible boronate ester formation
von: Leung, I, et al.
Veröffentlicht: (2011)

Modern NMR techniques for chemistry research /
von: 265053 Derome, Andrew E.
Veröffentlicht: (1987)

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases
von: Shishodia, S, et al.
Veröffentlicht: (2018)

Development of a Method for the N-Arylation of Amino Acid Esters with Aryl Triflates
von: King, Sandra M, et al.
Veröffentlicht: (2018)

Radiolabelling of aryl boronic esters with 18F and 123I: method development and application
von: McSweeney, G
Veröffentlicht: (2017)

Sequential catalysis: Exploiting a single rhodium(I) catalyst to promote an alkyne hydroacylation–aryl boronic acid conjugate addition sequence
von: Fernández, M, et al.
Veröffentlicht: (2016)

Studies on the reaction of glutathione and formaldehyde using NMR.
von: Hopkinson, R, et al.
Veröffentlicht: (2010)

Intermediates in the intermolecular, asymmetric Heck arylation of dihydrofurans
von: Hii, K, et al.
Veröffentlicht: (1997)

Glycosylation of the primary binding pocket of a subtilisin protease causes a remarkable broadening in stereospecificity in peptide synthesis
von: Matsumoto, K, et al.
Veröffentlicht: (2001)

Mechanism of phosphinidene complex arylation by arylboronic acids
von: Ng, Yong Xiang, et al.
Veröffentlicht: (2014)

NMR of drugs and ligands bound to membrane receptors.
von: Watts, A
Veröffentlicht: (1999)

Chemically modified "polar patch" mutants of subtilisin in peptide synthesis with remarkably broad substrate acceptance: designing combinatorial biocatalysts.
von: Matsumoto, K, et al.
Veröffentlicht: (2002)

"Pure by NMR"?
von: Claridge, T, et al.
Veröffentlicht: (2008)

REVISED STRUCTURES FOR TU 1718B AND VALCLAVAM
von: Baldwin, J, et al.
Veröffentlicht: (1993)

Palladium-catalysed intramolecular enolate O-arylation and thio-enolate S-arylation: synthesis of benzo[b]furans and benzo[b]thiophenes
von: Willis, M, et al.
Veröffentlicht: (2006)

Structural Insights into Bound Water in Crystalline Amino Acids: Experimental and Theoretical [superscript 17] O NMR
von: Craigen, Kimberley N., et al.
Veröffentlicht: (2017)

Characterization of neurotensin bound to the neurotensin receptor: An NMR study.
von: Williamson, P, et al.
Veröffentlicht: (2000)

Conformationally restricted arene intermediates in the intermolecular heck arylation of vinylarenes
von: Hii, K, et al.
Veröffentlicht: (2004)

Arylsulfonyl fluoride boronic acids: preparation and coupling reactivity
von: Lou, TS-B, et al.
Veröffentlicht: (2019)

Boronic acid and nitrofuranyl derivatives as potential therapeutics
von: Dey, AL
Veröffentlicht: (2021)

Expanding the utility of proteases in synthesis: broadening the substrate acceptance in non-coded amide bond formation using chemically modified mutants of subtilisin
von: Khumtaveeporn, K, et al.
Veröffentlicht: (2001)