The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program
The UK islet allotransplant program is nationally funded to deliver one or two transplants over 12 months to individuals with type 1 diabetes and recurrent severe hypoglycemia. Analyses were undertaken 10 years after program inception to evaluate associations between transplanted mass; single versus...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2021
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| _version_ | 1826281822141546496 |
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| author | Forbes, S Flatt, AJ Bennett, D Crookston, R Pimkova, M Birtles, L Pernet, A Wood, RC Burling, K Barker, P Counter, C Lumb, A Choudhary, P Rutter, MK Rosenthal, M Sutherland, A Casey, J Johnson, P Shaw, JAM |
| author_facet | Forbes, S Flatt, AJ Bennett, D Crookston, R Pimkova, M Birtles, L Pernet, A Wood, RC Burling, K Barker, P Counter, C Lumb, A Choudhary, P Rutter, MK Rosenthal, M Sutherland, A Casey, J Johnson, P Shaw, JAM |
| author_sort | Forbes, S |
| collection | OXFORD |
| description | The UK islet allotransplant program is nationally funded to deliver one or two transplants over 12 months to individuals with type 1 diabetes and recurrent severe hypoglycemia. Analyses were undertaken 10 years after program inception to evaluate associations between transplanted mass; single versus two transplants; time between two transplants and graft survival (stimulated C-peptide >50 pmol/L) and function. In total, 84 islet transplant recipients were studied. Uninterrupted graft survival over 12 months was attained in 23 (68%) single and 47 (94%) (p = .002) two transplant recipients (separated by [median (IQR)] 6 (3–8) months). 64% recipients of one or two transplants with uninterrupted function at 12 months sustained graft function at 6 years. Total transplanted mass was associated with Mixed Meal Tolerance Test stimulated C-peptide at 12 months (p < .01). Despite 1.9-fold greater transplanted mass in recipients of two versus one islet infusion (12 218 [9291–15 417] vs. 6442 [5156–7639] IEQ/kg; p < .0001), stimulated C-peptide was not significantly higher. Shorter time between transplants was associated with greater insulin dose reduction at 12 months (beta −0.35; p = .02). Graft survival over the first 12 months was greater in recipients of two versus one islet transplant in the UK program, although function at 1 and 6 years was comparable. Minimizing the interval between 2 islet infusions may maximize cumulative impact on graft function. |
| first_indexed | 2024-03-07T00:34:35Z |
| format | Journal article |
| id | oxford-uuid:80f4994a-a356-4faf-a47e-0b5ad568b2cb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:34:35Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:80f4994a-a356-4faf-a47e-0b5ad568b2cb2022-03-26T21:27:01ZThe impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant programJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:80f4994a-a356-4faf-a47e-0b5ad568b2cbEnglishSymplectic ElementsWiley2021Forbes, SFlatt, AJBennett, DCrookston, RPimkova, MBirtles, LPernet, AWood, RCBurling, KBarker, PCounter, CLumb, AChoudhary, PRutter, MKRosenthal, MSutherland, ACasey, JJohnson, PShaw, JAMThe UK islet allotransplant program is nationally funded to deliver one or two transplants over 12 months to individuals with type 1 diabetes and recurrent severe hypoglycemia. Analyses were undertaken 10 years after program inception to evaluate associations between transplanted mass; single versus two transplants; time between two transplants and graft survival (stimulated C-peptide >50 pmol/L) and function. In total, 84 islet transplant recipients were studied. Uninterrupted graft survival over 12 months was attained in 23 (68%) single and 47 (94%) (p = .002) two transplant recipients (separated by [median (IQR)] 6 (3–8) months). 64% recipients of one or two transplants with uninterrupted function at 12 months sustained graft function at 6 years. Total transplanted mass was associated with Mixed Meal Tolerance Test stimulated C-peptide at 12 months (p < .01). Despite 1.9-fold greater transplanted mass in recipients of two versus one islet infusion (12 218 [9291–15 417] vs. 6442 [5156–7639] IEQ/kg; p < .0001), stimulated C-peptide was not significantly higher. Shorter time between transplants was associated with greater insulin dose reduction at 12 months (beta −0.35; p = .02). Graft survival over the first 12 months was greater in recipients of two versus one islet transplant in the UK program, although function at 1 and 6 years was comparable. Minimizing the interval between 2 islet infusions may maximize cumulative impact on graft function. |
| spellingShingle | Forbes, S Flatt, AJ Bennett, D Crookston, R Pimkova, M Birtles, L Pernet, A Wood, RC Burling, K Barker, P Counter, C Lumb, A Choudhary, P Rutter, MK Rosenthal, M Sutherland, A Casey, J Johnson, P Shaw, JAM The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program |
| title | The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program |
| title_full | The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program |
| title_fullStr | The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program |
| title_full_unstemmed | The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program |
| title_short | The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program |
| title_sort | impact of islet mass number of transplants and time between transplants on graft function in a national islet transplant program |
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