Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression.
BACKGROUND: We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation. AIMS: To test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region invo...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826281825527398400 |
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| author | Mannie, Z Norbury, R Murphy, SE Inkster, B Harmer, C Cowen, P |
| author_facet | Mannie, Z Norbury, R Murphy, SE Inkster, B Harmer, C Cowen, P |
| author_sort | Mannie, Z |
| collection | OXFORD |
| description | BACKGROUND: We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation. AIMS: To test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region involved in the integration of emotional and cognitive information. METHOD: Eighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task. RESULTS: Controls showed significant activation in the pregenual anterior cingulate cortex to both positive and negative words during the emotional Stroop task. This activation was absent in FH+ participants. CONCLUSIONS: Our findings show that people at increased familial risk of depression demonstrate impaired modulation of the anterior cingulate cortex in response to emotionally valenced stimuli. |
| first_indexed | 2024-03-07T00:34:38Z |
| format | Journal article |
| id | oxford-uuid:80fa3096-61d0-460e-a267-6f95f38f4543 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:34:38Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:80fa3096-61d0-460e-a267-6f95f38f45432022-03-26T21:27:09ZAffective modulation of anterior cingulate cortex in young people at increased familial risk of depression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:80fa3096-61d0-460e-a267-6f95f38f4543EnglishSymplectic Elements at Oxford2008Mannie, ZNorbury, RMurphy, SEInkster, BHarmer, CCowen, PBACKGROUND: We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation. AIMS: To test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region involved in the integration of emotional and cognitive information. METHOD: Eighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task. RESULTS: Controls showed significant activation in the pregenual anterior cingulate cortex to both positive and negative words during the emotional Stroop task. This activation was absent in FH+ participants. CONCLUSIONS: Our findings show that people at increased familial risk of depression demonstrate impaired modulation of the anterior cingulate cortex in response to emotionally valenced stimuli. |
| spellingShingle | Mannie, Z Norbury, R Murphy, SE Inkster, B Harmer, C Cowen, P Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. |
| title | Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. |
| title_full | Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. |
| title_fullStr | Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. |
| title_full_unstemmed | Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. |
| title_short | Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. |
| title_sort | affective modulation of anterior cingulate cortex in young people at increased familial risk of depression |
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